Formulation of micro-dispersions of polysaccharides and lipids for development of colon delivery system

在药物递送系统(DDS)中，为了将功能成分靶向到靶器官，需要进行材料设计。本研究致力于开发具有高载药量和结肠靶向可能性的功能化合物的包埋新原理。为了利用变性淀粉稳定O/W乳状液，对各种淀粉进行了形态表征，并对天然淀粉进行了疏水改性和表征。N-辛烯基琥珀酸酐改性藜麦淀粉对水包油乳化液具有较好的乳化效果。丁酸结肠给药系统将丁酸-壳聚糖水相与三棕榈素混合，得到稳定的W/O乳状液。此外，还对胡萝卜进行了粉碎，发现高压均质机在微碱性、沸腾条件下可制得亚微米胡萝卜纤维。

In DDS (Drug Delivery System), material design will be needed in order to target functional components into targeted organ. This research was focused on developing new principle for the encapsulation of functional compounds with high carrying capacity and the possibility of colon targeting. Morphological characterization of various starches, as well as hydrophobic modification and characterization of native starch, for the purpose of using modified starch to stabilize O/W emulsions were carried out. n-Octenyl succinic anhydride modified-quinoa starch was found to be effective for oil in water emulsification. For colon delivery system of butyric acid, butyric acid-chitosan aqueous phase was mixed with tripalmitin for getting stable W/O emulsions. Besides these, pulverization of carrot was conducted, and submicron carrot-based fiber was found to be formulated by high pressure homogenizer at slightly alkali, boiling conditions.