Genome epidemiologic study on lung cancer and inflammation-related genes

慢性炎症与肺癌的发展有关。本研究的目的是评估炎症相关的多态性与肺癌之间的关系以及这些多态性对吸烟与肺癌风险之间关系的修饰作用。我们对IL 1B-511 T>C、IL 1B-31 C>T、IL 1B 3954 C>T、IL 6 rs 1800796、IL 10 rs 1800871、IL 13 rs 1800925、TNFA rs 1799724、TNFR 2 rs 1061622、MPO rs 2333227、CRPrs 2794520、COX 2 rs 5275、采用非条件Logistic回归分析方法，计算OR值和95%CI。CRP rs 2794520基因多态性与肺癌风险显著相关（CT基因型与TT基因型的OR = 1.59，95% CI = 1.14 ~ 2.22; CC基因型与TT基因型的OR = 1.92，95% CI = 1.10-3.38），而其他基因多态性与肺癌风险无关。IL 1B-511 T>C、CRP rs 2794520或PPARG rs 13073869多态性与吸烟之间的交互作用显著。吸烟和其余多态性之间没有显著的相互作用。需要进一步的研究来阐明炎症相关的多态性和吸烟多态性相互作用对肺癌的影响。

Chronic inflammation has been implicated in the development of lung cancer. The aims of this study were to evaluate the association between inflammation- related polymorphismsand lung cancer and the modifying effects of the polymorphisms on the association of cigarette smoking with lung cancer risk. We genotyped IL1B -511T>C, IL1B -31C>T, IL1B 3954C>T, IL6 rs1800796, IL10 rs1800871, IL13 rs1800925, T NFA rs1799724, TNFR2 rs1061622, MPO rs2333227, CRPrs2794520, COX2 rs5275, PPARG rs13073869 and PPARG rs4135249 polymorphisms in Japanese.Unconditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (95% CI). The CRP rs2794520 polymorphism was significantly associated with lung cancer risk (OR for CT genotype vs. TT genotype = 1.59, 95% CI = 1.14 - 2.22; OR for CC genotype vs.TT genotype = 1.92, 95% CI = 1.10-3.38) while other polymorphisms were not. The interactions between either the IL1B -511 T>C, CRP rs2794520 or PPARG rs13073869 polymorphisms and smoking were significant. There were no significant interactions between smoking and either of the remaining polymorphisms. Additional studies are required to clarify the effects of the inflammation-related polymorphisms and the smoking-polymorphism interactions on lung cancer.