The creation and application of lifestyle-related diseases in the hyperlipidemia mouse.

我们评价了高胆固醇饮食对欧洲木鼠(Apodemus Sylvaticus)动脉内皮功能的影响，其中一些在正常饮食下会自发表现出高脂血症。根据血浆胆固醇水平将小鼠分为两组：高胆固醇组和正常胆固醇组。两只小鼠均以正常或高胆固醇饮食喂养5周。高胆固醇饮食增加了两组的血浆总胆固醇水平。高胆固醇喂养后，两组小鼠的离体主动脉内皮依赖性舒张功能均恶化。因此，内皮依赖性的松弛受到抑制，依赖于血浆总胆固醇水平。

We evaluated the effect of high cholesterol diet on endothelial function of artery from European wood mice(Apodemus Sylvaticus), some of which spontaneously exhibit hyperlipidemia on a normal diet. According to the plasma cholesterol level, mice were divided into two groups ; hypercholesterol mice and normocholesterol mice. Both mice were fed with a normal or high-cholesterol diet for 5 weeks. The high-cholesterol diet increased the total plasma cholesterol level in both groups. The endothelium-dependent relaxation of isolated aorta was worsened in both mice after high cholesterol feeding. Thus, the endothelium-dependent relaxation was inhibited depending on the total plasma cholesterol level.