Regulation of intestinal symbiotic system and inflammatory reactions by food

分析肠道寄生菌与肥大细胞和上皮细胞的相互作用。研究表明，肠道寄生菌影响肥大细胞的终末分化，并调节肠道上皮细胞中参与微生物识别的基因的表达。肠道细菌调节肥大细胞和肠上皮细胞功能的这些机制可能为肠道内稳态紊乱引起的炎症反应的调节提供有用的靶点。

Interaction of intestinal commensal bacteria with mast cells and epithelial cells was analyzed. It was shown that intestinal commensal bacteria affect the terminal differentiation of mast cells and they regulate expression of the genes which are involved in recognition of microbes in intestinal epithelial cells. These mechanisms underlying modulation of the functions of mast cells and intestinal epithelial cells by commensal bacteria may provide a useful target for the regulation of inflammatory reactions which are caused by the disorder of intestinal homeostasis.