Developments and applications of multifunctional catalytic molecules based on the creation of novel asymmetric reaction space

目前的研究主要有以下几个方面。(1)我们发展了一种钯催化的分子内苯酚的ipso-Friedel-Crafts烯丙基烷基化反应，为合成螺环己二烯酮提供了一条新的途径。(2)开发了新型双齿型二氨基氧化膦预配体，并将其应用于催化有机合成。此外，还实现了唐古托碱的催化不对称全合成。(3)开发了一种新型的基于4，5-二氨基氧杂蒽骨架的双功能氢键给体催化剂。这些催化剂适用于前手性亲核试剂对硝基苯乙烯的不对称共轭加成反应，以构建全碳四元立构中心。

The present researches can be summarized as follow. (1) We developed a Pd-catalyzed intramolecular ipso-Friedel-Crafts allylic alkylation of phenols, which provided a new access to spirocyclohexadienones. (2) Novel bidentate-type diaminophosphine oxide preligands were developed and applied to catalytic organic synthesis. In addition, catalytic asymmetric total synthesis of tangutorine was achieved. (3) Novel bifunctional hydrogen bond-donor catalysts based on a 4,5-diaminoxanthene skeleton were developed. These catalysts were applicable to enantioselective conjugate addition of prochiral nucleophiles to nitrostyrenes for constructing an all carbon quaternary stereocenter.