Elucidation of mechanism for polarized regulation of viral RNA synthesis of negative-strand RNA viruses

本研究旨在阐明病毒RNA合成的极化调节机制，这是病毒有效复制所必需的，我们发现C蛋白是仙台病毒的辅助蛋白之一，是负链病毒的原型，它以时间依赖的方式下调(+)正义病毒的合成，并最大限度地产生感染性后代病毒粒子。此外，在本研究过程中，我们还发现了一种可能性，即C蛋白调节病毒RNA的合成以逃避宿主先天免疫的检测。

In this study aimed at elucidation of mechanism of polarized regulation of viral RNA synthesis, which should be required for efficient viral replication, we found that the C protein, one of the accessory protein of Sendai virus, a prototype of negative-stranded viruses, down-regulated (+)-sense viral RNA synthesis in a time-dependent manner and maximized production of infectious progeny virions. In addition, in the course of this study, we also found a possibility that the C protein regulate viral RNA synthesis to escape from detection by host innate immunity.