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Role of muscarinic acetylcholine receptor in the development of transplant arteriosclerosis

Role of muscarinic acetylcholine receptor in the development of transplant arteriosclerosis
毒蕈碱乙酰胆碱受体在移植动脉硬化发展中的作用
批准号:
21791247
负责人:
MATSUMOTO Yuji
金额:
$2.75万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010

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中文摘要
翻译
我们研究了毒蕈碱型乙酰胆碱受体(mAChR)在移植动脉硬化发生中的作用。从mAChR缺陷型小鼠和野生型(WT)小鼠的骨髓中分离单核白细胞。使用Boyden室系统检查细胞迁移。从mAChR缺陷小鼠中收获的细胞中,卡巴胆碱诱导的白细胞迁移显著减少。这些结果表明,mAChR介导的白细胞迁移可能在移植动脉硬化的发展中发挥重要作用。
英文摘要
We investigated the role of muscarinic acetylcholine receptor (mAChR) in the development of transplant arteriosclerosis. Mononuclear leukocytes were isolated from bone-marrow of mAChR deficient mice and wild-type (WT) mice. Cell migration was examined using a Boyden chamber system. Carbachol-induced leukocyte migration was significantly reduced in the cells harvested from mAChR-deficient mice. These results suggest that mAChR-mediated leukocyte migration may play an important role in the development of transplant arteriosclerosis.
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会议论文
M1 and M5 muscarinic acetylcholine receptor-mediated leukocyte migration
M1 和 M5 毒蕈碱乙酰胆碱受体介导的白细胞迁移
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Kosuke Harada, Yuji Matsumoto, Kazuo Umemura]
通讯作者: Kazuo Umemura
ムスカリン性アセチルコリン受容体を介した白血球遊走
白细胞通过毒蕈碱乙酰胆碱受体迁移
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Marimo Sato, Kimiyasu Yoneyama, Takafumi Nakamura, Hisako Katano, Yuko Kitagawa, Hideaki Tahara, 松本祐直]
通讯作者: 松本祐直
Nanoscale Engineering of Compositional Modulations in Alloys and Composite Thin Film Oxides for Exploration of Their New Properties and Functionalities
  • 批准号:
    20H02610
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 资助金额:
    $11.48万
  • 财政年份:
    2020
  • 负责人:
    MATSUMOTO Yuji
  • 依托单位:
Development of a comprehensive educational method of algorithmic design for the expansion of creativity using IT
  • 批准号:
    19K12680
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.75万
  • 财政年份:
    2019
  • 负责人:
    MATSUMOTO Yuji
  • 依托单位:
Nano-strained interfaces in nanocomposite ferroelectric films and the origin of their free polarization rotation
  • 批准号:
    15H02021
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
  • 资助金额:
    $27.12万
  • 财政年份:
    2015
  • 负责人:
    MATSUMOTO Yuji
  • 依托单位:
Development of site-specific nuclease to control mutated mtDNA in MELAS iPS cell-derived neuronal cells
  • 批准号:
    26860831
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
  • 资助金额:
    $2.5万
  • 财政年份:
    2014
  • 负责人:
    MATSUMOTO Yuji
  • 依托单位:
海外基金