The role of orphan receptor, TROY, in the proliferation and differentiation of glioma stem cells

我们已经报道，Troy在脑室下区(SVZ)的GFAP阳性神经干细胞和/或星形胶质前体细胞中表达。在本研究中，我发现TROY的配体LTα在成年小鼠的脑室下区表达。最近有报道称，脑肿瘤干细胞可能来源于正常的神经干细胞或SVZ的祖细胞。我在U251胶质瘤细胞中发现CD133阳性的胶质瘤干细胞表达Troy。这些结果阐明了SVZ中Troy阳性/GFAP阳性的神经干细胞和CNS中Troy阳性/CD133阳性的胶质瘤干细胞之间的关系。

We have reported that TROY was expressed in the GFAP-positive neural stem cells and/or astroglial progenitor cells in the subventricular zone (SVZ). In the present study, I showed that LTα, a ligand of TROY, was expressed in these GFAP-positive cells in the subventricular zone (SVZ) of adult mice. Recently, it has been reported that brain tumor stem cells might be derived from normal neural stem or progenitor cells of the SVZ. I found the expression of TROY in CD133-positive glioma stem cells in U251 glioma cells. These results shed light on the association of TROY-positive/GFAP-positive neural stem cells in the SVZ and TROY-positive/CD133-positive glioma stem cells in the CNS.