Peroxisome proliferator-activated receptor gamma polymorphism andperiodontitis, preterm birth and obesity in pregnant Japanese women

PPARγ是一种核激素受体，调节脂质代谢和炎性细胞因子的产生。一种功能性遗传多态Pro12Ala已被报道。最近的研究表明，牙周炎与早产或肥胖之间存在关联。我们调查了日本孕妇中PPARγ基因多态性与牙周炎、早产和肥胖的关系。牙周炎与早产或牙周炎与肥胖之间没有明显的关联。然而，在日本孕妇中发现了该基因多态与牙周炎的显著关联。

PPAR gamma is a nuclear hormone receptor which regulates lipid metabolism and production of inflammatory cytokines. A functional genetic polymorphism Pro12Ala has been reported. Recent studies have suggested an association between periodontitis and preterm birth or obesity. We investigated relationships between PPAR gamma polymorphism, periodontitis, preterm birth and obesity in pregnant Japanese women. There was no significant association between periodontitis and preterm birth, or between periodontitis and obesity. However, a significant association of the polymorphism and periodontitis was found in the Japanese pregnant women.