New development of studies on the interaction between cell membranes and drugs using sensors

利用离子传感器和氧电极等电化学传感器分析了阳离子卟啉和杂蒽染料如何使细胞膜光失活。此外，我们将K+传感器应用于细胞膜通透性测定，并推进了(1)开发具有低溶血活性的抗菌肽；(2)乳突蛋白及相关组胺释放剂在细菌、红细胞和肥大细胞中的膜渗透活性的比较研究；(3)革兰氏阴性菌外膜增强新物质的研究。

We analyzed how cationic porphyrins and xanthene dyes photoinactivated cell membranes using electrochemical sensors, such as ion sensor and oxygen electrode. Furthermore, we applied a K+sensor to cell membrane permeability assay and advanced(1) the development of antimicrobial peptides with low hemolytic activity;(2) the comparative study of the membrane-permeabilizing activities of mastoparans and related histamine-releasing agents in bacteria, erythrocytes, and mast cells; and(3) the investigation of new substances that enhance the outer membrane of Gram-negative bacteria.