MG23-mediatedcrosstalk between genetic system and immune system.

内质网（ER）对各种应激进行适应性反应，决定细胞命运。在这里，我们发现ER蛋白mitsugumin 23（MG 23）的敲低增强了紫外线C（UVC）诱导的细胞死亡，这会导致DNA损伤。小的热休克蛋白α B-晶状体蛋白（αBC）被鉴定为MG 23结合分子，其敲低促进了暴露于UV C的细胞的死亡。相反，当表达为ER锚定形式时，αBC降低UVC敏感性。综上所述，结果表明MG 23通过在ER附近积累αBC而对UVC起保护作用。

The endoplasmic reticulum (ER) operates in adaptive responses to various stresses, dictating cell fate. Here we show thatknockdown of the ER protein mitsugumin23 (MG23) enhances cell death induced by ultraviolet C (UVC), which causes DNA damage. The small heat shock protein αB-crystallin (αBC) is identified as a MG23 binding molecule and its knockdown facilitates death of UVC-exposed cells. Conversely, αBC lowered UVC sensitivity when expressed as an ER-anchored form. Taken together, the results suggest that MG23plays a protective role against UVC by accumulating αBC in the close vicinity of the ER.