Establishment of the therapy of diastolic heart failure

本研究的目的是使用我们的前瞻性观察性研究CHART-2（东北地区慢性心力衰竭分析和登记-2）来确定营养状况对舒张性心力衰竭（DHF）患者预后的影响。在入组时，通过CONUT评分评估其营养状况，CONUT评分是一种广泛使用的营养状况评分，代表血清白蛋白、总胆固醇水平和总淋巴细胞计数的综合影响。经性别、年龄、CAD病史、Cre、LVEF、贫血和癌症病史校正后，CONUTS β 5是DHF患者的独立预后指标。营养不良是心源性死亡的重要预测因素，也是DHF患者的新治疗靶点。

The purpose of this study was to determine the prognostic impact of nutritional status in patients with diastolic heart failure (DHF) using our prospective observational study named the CHART-2 (Chronic Heart failure Analysis and Registry in the Tohoku district-2). At the enrollment, their nutritional status was assessed by the CONUT score, a widely used nutritional status score representing the combined impact of serum albumin, total cholesterol level, and total lymphocyte count. After adjustment by sex, age, history of CAD, Cre, LVEF, anemia, and history of cancer, CONUTS〓5 was an independent prognostic marker in the patients with DHF. Undernutrition is an important predictor for cardiac death and a novel therapeutic target in patients with DHF.