Biological study of obsessive-compulsive disorder using brain imaging and the molecular genetics

对89例强迫症患者和89例健康对照进行了5HTT - lpr的L型和s型多态性基因分型。因此，目前和/或过去共病抑郁症的强迫症患者在统计学上具有更高的l等位基因频率。结果提示l等位基因可能与抑郁症与强迫症的共病有关。对37例强迫症患者和37例健康对照进行磁共振成像检查。我们发现强迫症患者的右侧后扣带皮层和其他一些区域与健康对照（hc）相比显著减少。此外，我们还发现了强迫症症状的类型与大脑特定区域的体积之间的特定相关性。强迫症的病理生理可能涉及广泛分布的神经系统。此外，症状维度与结构异常之间存在明显的相关性。

Eighty-nine obsessive and compulsive disorder (OCD) patients and 89 healthy controls were genotyped with L- and s- types polymorphisms of 5HTT -LPR. As a result, OCD patients with current and/or past comorbid depression had a statistically higher frequency of the L-allele. The result suggested that the L-allele might be associated with the comorbidity depression with OCD.Magnetic resonance imaging examinations of 37 OCD patients and 37 healthy controls (HCs) were carried out. W e found significant reductions in right posterior cingulate cortexand some other areas in the OCD patients compared to healthy controls (HCs). In addition, we found specific correlations between the type of the obsession symptom and the volume of the specific area of the brain. The pathophysiology of OCD may involve widely distributed neural systems. Moreover, there are distinct correlations among symptomatic dimensions and structural abnormalities.