Bone regeneration using autologous fibrin gel with adipose derived stem cells

脂肪干细胞(ADSCs)是从脂肪组织中提取的具有高增殖能力和多能性的干细胞。本研究的目的是开发一种利用脂肪干细胞和纤维蛋白凝胶进行骨再生的方法。当ADSCs在不含BMP-2的成骨培养液中培养时，ADSCs向成骨细胞的分化不充分。另一方面，将自体纤维蛋白凝胶植入鼻窦等封闭的腔内，可见骨再生，为骨再生创造了空间。

Adipose derived stem cells(ADSCs), which have high proliferation potency and pluripotency, can be extracted from adipose tissue. The purpose of this study was to develop a bone regeneration using ADSCs and fibrin gel. When ADSCs were cultured in osteogenic medium without BMP-2, differentiation of ADSCs into osteoblastic cells was not sufficient. On the other hand, bone regeneration was seen when autologous fibrin gel was grafted into a closed cavity such as sinus making a space for bone regeneration.