Application of oncolytic adenovirus to the Exfoliative cytodiagnosis

本研究旨在以口腔鳞状细胞癌为靶点，利用反式酶特异性溶瘤腺病毒进行临床应用诊断和治疗的基础研究。结果，目前已感染Telomescan的人口腔鳞癌细胞系，我们研究了可能的可视化，观察到一段时间内GFP的荧光染色。因此，我们寻求在临床标本中显示癌细胞的可能性。以口腔癌患者为模型，将口腔鳞状细胞癌细胞接种于健康人口腔正常粘膜，用TELOMESCAN感染后呈现绿色荧光蛋白的彩色荧光。

In this study, the aim of clinical application of diagnosis and treatment of basic research that targets oral squamous cell carcinoma, using teromerase specific oncolytic adenovirus. A result, it is currently infected with Telomescan to human oral squamous cell carcinoma cell line, we studied possible visualization, GFP fluorescence was observed over a period of time coloring. Therefore, we search for the possibility of visualization of cancer cells in clinical specimens. The tumor as a model of oral cancer patients, in which oral squamous cell carcinoma cells were seeded in oral normal mucosa of healthy persons, were infected with Telomescan showed a color fluorescence of GFP.