DNA methylation-based diagnosis of cancer and identification of novel therapeutic targets

在我们老龄化的社会，癌症是一个严重的经济和生活质量威胁。DNA甲基化关闭了基因，最近有研究表明，DNA甲基化缺陷会导致包括癌症在内的人类疾病。这个项目将确定与癌症相关的DNA甲基化缺陷。识别这些缺陷将使我们能够设计对血液或身体排泄物进行癌症的非侵入性早期诊断测试，并寻求治疗癌症的新的治疗方法。预期的结果将产生对美国和欧洲市场的出口，并取代治疗癌症的药物和技术的进口。

In our aging society, cancer represents a severe economic and quality-of-life threat. DNA methylation switches genes off, and recently, it was shown that defects in DNA methylation contribute to human diseases including cancer. This project will identify defects in DNA methylation associated with cancer. Identifying these defects will enable us to design non-invasive, early diagnostic tests for cancer on blood or bodily excretions, and to pursue novel therapeutic approaches for treating cancer. The expected outcomes would generate exports to markets in the USA and Europe and replace imports of drugs and technology to treat cancer.