Analysis for physiological role of the Ca2+-binding ER protein calumin

钙蛋白是内质网上的跨膜蛋白。尽管钙蛋白敲除在E10左右的小鼠胚胎中是致命的。5-11。5、生理作用不明确。因此，我们研究了钙蛋白的生理作用。钙蛋白在主要的营养转运细胞卵黄囊内胚层细胞中特异表达。此外，脂滴在敲除钙蛋白的卵黄囊内胚层细胞中积累。因此，钙蛋白参与了内胚层细胞的脂质转运。

Calumin is transmembrane protein on endoplasmic reticulum. Although calumin knockout in mice is embryonic lethal around E10. 5-11. 5, the physiological role is no clear. Thus, we investigated the physiological role of calumin. Calumin is specifically expressed in yolk sac endoderm cells which are the principal nutrient-transporting cells. Additionally, lipid droplets are accumulated in calumin knockout yolk sac endoderm cells. Therefore, it was suggested that calumin was involved in lipid transport in endoderm cells.