Chemoprevention for gastric carcinogenesis by inhibition of renin-angiotensin system

在12个月的观察期内，未感染幽门螺杆菌的动物胃粘膜AT1R和AT2R mRNA /β-肌动蛋白mRNA的比值几乎为零。另一方面，野生型幽门螺杆菌处理动物的AT1R和AT2R mRNA比值随着时间的推移逐渐升高。跨国公司浸润评分中位数与AT1R和AT2R水平显著相关。与野生型相比，caga和oipa敲除菌株引起的炎症明显较轻。发生胃溃疡的沙鼠的AT1R和AT2R mRNA水平显著高于未发生胃溃疡的沙鼠，提示RAS抑制剂可能对胃癌发生具有化学预防作用。

Gastric mucosal AT1R and AT2R mRNAs/β-actin mRNA ratios were approximately zero in H. pylori uninfected animals throughout the 12-month observation period. On the other hand, both AT1R and AT2R mRNA ratios in animals treated with wild-type H. pylori gradually increased during the time course. The median MNCs infiltration score was significantly correlated with AT1R and AT2R levels. The cagA-and oipA-knockout strain induced significantly milder inflammation compared with the wild-type. AT1R and AT2R mRNA levels were significantly higher in gerbils that developed gastric ulcers than in gerbils without gastric ulcer, suggested that RAS inhibitors may have chemoprevention for gastric carcinogenesis.