Assessment of bone tissue as a central regulator for hematopoiesis

骨细胞是骨组织中的主要细胞成分。我们利用骨细胞特异性表达白喉毒素受体（DTR）的DMP 1-DTR Tg小鼠模型，通过注射白喉毒素诱导无骨细胞（OL）小鼠的产生，来揭示骨细胞在骨髓龛和远端器官中的功能。我们发现骨细胞向成骨细胞龛发出支持信号，这一信号通路受交感神经系统控制。此外，我们发现骨细胞调节初级淋巴器官，如胸腺和脂肪代谢。我们的研究提出了“多器官功能协调的骨尖峰”。

Osteocytes are a major cell component in the bone tissue. We utilized DMP1-DTR Tg mouse model, in which diphteria toxin receptor (DTR) is specifically expressed in osteocytes and diphteria toxin injection induces the generation of osteocyte-less (OL) mouse, to reveal the the function of osteocytes for bone marrow niche and remote organs. We found that osteocytes send a supporting signal to osteoblastic niche and this pathway is controlled by the sympathetic nervous system. Furthermore, we showed that osteocytes regulate primary lymphoid organs such as thymus and fat metabolism. Our study proposes "the bone pinnacled functional orchestration of multiple organs".