Isolation of pluriptent somatic stem cells for neuronal regenerative medicine and neuronal differentiation peptide-mediated neuronal differentiation

我们使用神经干细胞和皮肤来源的间充质干细胞作为神经谱系的多能体细胞干细胞。11种BC-box蛋白（SOCS1-7, ASB3, WSB2, LRR1， VHL）衍生的功能肽被递送到这些体细胞干细胞。每个肽诱导分化不同类型的神经元。诱导VHL和socs7衍生肽分化多巴胺能神经元和运动神经元，诱导socs5衍生肽分化视网膜颜色上皮细胞和谷氨酸神经元。这种神经元分化的机制被认为与Stat3的退化有关，但仍在研究中。

We used neural stem cells and skin-derived mesenchymal stem cells as pluripotent somatic stem cells to neuronal lineage. Eleven BC-box proteins(SOCS1-7, ASB3, WSB2, LRR1, VHL)-derived functional peptides are delivered to those somatic stem cells. Each peptide induced to differentiate different type of neuron. VHL and socs7-derived peptides induced to differentiate dopaminergic and motor neurons, and SOCS5-derived peptide induced to differentiate retinal color epithelial cells and gultamate neuron. This mechanism of neuronal differentiation is suggested to be related to degeradation of Stat3, but is under investigation.