Establishment of a new strategy for the treatment of spinal cord injury: Intrathecal administration of incubated autologous bone marrow stromal cells.

为探讨自体骨髓细胞鞘内注射治疗亚急性脊髓损伤是否安全可行，纳入5例颈椎损伤所致四肢瘫痪和5例胸椎损伤所致截瘫患者。从自体髂骨中提取约100万个单核细胞，通过腰椎穿刺法立即注入脑脊液中。对患者进行6个月的密切观察。未观察到不良反应。在早期治疗的少数患者中，明确的运动和感觉恢复是显著的，但在后来治疗的患者中有限。亚急性期早期脑脊液中注入骨髓细胞治疗脊髓损伤是安全可行的。

To determine whether intrathecal administration of autologous bone marrow cells is safe and feasible for treatment of subacute spinal injury, five patients with tetraplegia due to cervical spinal injury and 5 with paraplegia due to thoracic spinal injury were included. About 1 million mononuclear cells were obtained from their own iliac bone, and administered immediately into cerebrospinal fluid by lumbar puncture. The patients were closely observed for 6 months. No adverse responses were observed. In a few patients treated earlier, definite motor and sensory recovery was remarkable, but limited in patients treated later. Spinal injury treatment with administration of bone marrow cells into cerebrospinal fluid is safe and feasible underwent in the early subacute phase.