Development of Innovative Targeting Artificial pulmonary surfactant preparations by Nanomedicine

人工肺表面活性物质（PS）中的模型肽在侧向压缩时其二级结构从α-螺旋变为β-折叠。然而，在阴离子脂质如磷脂酰甘油和棕榈酸的存在下，发现从光谱方面防止结构的转化。含氟化合物添加剂对PS的制备也有很好的效果.从热力学、形态学和光谱学的角度阐明了PS在界面上的作用机制。

The model peptide in artificial pulmonary surfactant (PS) changes its secondary structure from alpha-helix to beta-sheet upon lateral compression. However, in the presence of anionic lipids such as phosphatidylglycerol and palmitic acid, the conversion of the structure is found to prevent from the spectroscopic aspect. And fluorinated compound additive in PS also very effective for PS preparation. The mechanism and function of PS across the interface have been elucidated from the thermodynamic, morphological, and spectroscopic perspectives.