Development and Biological Chemistry of Novel Platinum Anti-Cancer Agents

“规则破坏者”，即不遵循已建立的结构/活性关系的铂抗癌络合物，已成为治疗对当前一代药物耐药的癌症和减少副作用的前进方向。我们已经开发了两组新的“规则破坏者”，它们已经展示了非常有希望的抗癌活性和新的生物行为。在这个项目中，我们将(I)基于这两组极具前景的化合物制备新的抗癌活性铂配合物，(Ii)确定这些药物的作用方式以及它们在生物环境中的作用。

"Rule-breakers", platinum anticancer complexes that do not follow the well established structure/activity relationships, have emerged as the way forward in the treatment of cancer resistant to the current generation of drugs and in reducing side effects. We have developed two new groups of "rule-breakers" and these have already demonstrated highly promising anticancer activity and novel biological behaviour. In this project we will (i) prepare new anticancer active platinum complexes based on these two highly promising groups of compounds and (ii) determine how these drugs work and what happens to them when in biological environments.