Investigation of the pathogenetic factors for the development of NASH

库普弗细胞过度分泌炎性细胞因子和库普弗细胞吞噬功能受损被认为是非酒精性脂肪性肝炎（NASH）发生的重要致病因素。我们发现，在NASH肝脏中，能够分泌炎症细胞因子的CD11b+ Kupffer细胞数量增加，而能够吞噬细胞和ROS产生的CD68+ Kupffer细胞数量减少。在分布上，与正常肝脏不同，库普弗细胞分布在NASH肝脏的整个肝叶上。国内外多场医学会议及部分文献均明确报道库普弗细胞亚群及分布的改变是NASH发生的重要致病因素。

Hyper-secretion of inflammatory cytokines from Kupffer cells and impairment of phagocytic function of Kupffer cells are considered to be important pathogenic factors for development of nonalcholic steatohepatitis (NASH). We clarified that number of CD11b+ Kupffer cells which enable to secrete inflammatory cytokines increase, and CD68+ Kupffer cells which enable to phagocyte and production of ROS decrease in NASH livers. In distribution, Kupffer cells distributed on whole hepatic lobes in the livers of NASH unlike normal livers. It was clarified and reported that the changes of subset and the distributions of Kupffer cells would be important pathogenic factors for development of NASH at several domestic and international medical meeting and some articles.