Analysis of angiogenetic factor in interstitial pneumonia

我们研究了间质性肺炎早期肺泡内纤维化过程的发病机制。我们发现特发性肺纤维化肺泡内纤维化病变的成纤维细胞分化为肌成纤维细胞，新生血管形成减少。然而，关于miroRNA在肺纤维化过程中的作用的信息有限。此外，肺纤维化过程中支气管肺泡灌洗液中的microRNA和外泌体microRNA未被研究。我们研究了博来霉素诱导的小鼠肺纤维化模型中支气管肺泡灌洗洪水中的外泌体microRNA。

We have been investigated pathogenesis of early intra-alveolar fibrotic process in interstitial pneumonia. We showed fibroblast differentiation into myofibroblast and decreased neovasculization in intra-alveolar fibrotic lesion of idiopathic pulmonary fibrosis. However, there is only limited information concerning the role of miroRNA in lung fibrotic process. Forthermore, microRNA and exosomal microRNA in bronchoalveolar lavage in lung fibrotic process are not investigated. We investigate exosomal microRNA in brochoalveolar lavage flood in mouse model of bleomycin induced lug fibrosis.