Participation of the adenosine receptor for amnesia effect of sedative and anesthetic agent

镇静和麻醉剂的镇静/催眠作用是通过伽玛-氨基丁酸受体实现的。此外，镇静和麻醉剂有效地抑制腺苷的摄取，从而积累细胞外的腺苷浓度，从而增强腺苷的作用。在这项研究中，我们评估了腺苷(神经调节剂)的遗忘作用。在轻度镇静时，给予腺苷前体5‘-三磷酸腺苷可增强失忆和镇静作用。氨茶碱可拮抗深度镇静时的镇静作用，也可拮抗深度镇静时的遗忘作用。这些结果清楚地表明，腺苷受体刺激增强了遗忘/镇静作用，而腺苷受体拮抗剂则减弱了遗忘/镇静作用。

Sedative/hypnotic effect of sedative and anesthetic agents occurs via Gamma-aminobutyric acid receptor. Moreover sedative and anesthetic agents potently inhibit adenosine uptake, thereby accumulating extracellular concentration of adenosine, and thus potentiate actions of adenosine. In this study, we evaluated the amnesic effect of adenosine (nuromodulator). Adenosine 5'-triphosphate (precursor of adenosine) administration enhanced amnesia and sedative effects during light sedation. Aminophylline administration antagonized the sedative effect but also the amnesic effect during deep sedation. These results clearly demonstrate that adenosine receptor stimulation potentiates the amnesic/sedative effect and adenosine receptor antagonism attenuate the amnesic/sedative effect.