Neurochemical study for post-operative delirium

术后谵妄的神经化学研究

• 批准号: 20591839
• 负责人: MURAKAWA Masahiro
• 金额: $ 2.91万
• 依托单位: Fukushima Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591839/
• 关键词: 術後せん妄; 吸入麻酔薬; 鎮静薬; 手術ストレス; アセチルコリン; 脳内微小透析法; 脳内マイクロダイアリースス; 疼痛; セボフルラン; エンフルラン; ハロタン; マイクロダイアリーシス; イソフルラン; ACTH; プロポフォール; ミダゾラム; デクスメデトミジン

To clarify the neurochemical basis for postoperative delirium, the changes of acetylcholine release in rat cerebral cortex by the painful stimulation during general anesthesia and by the sedation were studied using brain microdialysis. The acetylcholine release was significantly affected by widely-used inhalational anesthetics and sedatives. The results of this study suggest that the occurrence of post-operative delirium is related to the changes in cholinergic neuronal activities in the brain.

为阐明术后谵妄的神经化学基础，本文用脑微透析技术研究了全麻时疼痛刺激和镇静剂对大鼠大脑皮层乙酰胆碱释放的影响。广泛使用的吸入麻醉药和镇静剂对乙酰胆碱释放有显著影响。本研究结果提示，手术后谵妄的发生与脑内胆碱能神经元活动的改变有关。

项目成果

Isoflurane suppresses the increase of acetylcholine release in the rat brain with surgical stress.

异氟醚抑制手术应激大鼠大脑中乙酰胆碱释放的增加。

• 发表时间: 2010
• 作者: Hakozaki T;Imaizumi T;Hosono A;Takahashi S;Murakawa M.
• 通讯作者: Murakawa M.

Effects of sedative drugs on acetyl choline release from rat cerebral cortex.

镇静药物对大鼠大脑皮层乙酰胆碱释放的影响。

• 发表时间: 2008
• 作者: Nemoto C;Hakozaki T;Obara S;Isosu T;Murakawa M.
• 通讯作者: Murakawa M.

Isoflurane suppresses the increase of acetylcholine release in the rat brain with surgical stress

异氟烷抑制手术应激大鼠大脑中乙酰胆碱释放的增加

• 发表时间: 2010
• 作者: Hakozaki T;et. al.
• 通讯作者: et. al.

Effects of Sedative Drugs on Acetylcholine Release from the Rat Cerebral Cortex

镇静药物对大鼠大脑皮层乙酰胆碱释放的影响

• 发表时间: 2008
• 作者: Nemoto C;Hakozaki T;Obara S;Isosu T;Murakawa M.;Nemoto C
• 通讯作者: Nemoto C