Newly approach of the interventional treatment for periodontitis in smokers;Suppresive effects by cadmium

在本研究中，我们使用人牙龈上皮细胞、人牙龈成纤维细胞、人股骨成骨细胞和商品化的人成骨细胞试剂盒，检测了细胞对镉(Cd)暴露的各种反应。不同类型的细胞对镉的反应不同，细胞类型和细胞因子浓度也不同。以上结果表明，烟草中Cd对吸烟者牙周组织有一定的损伤作用。此外，在镉暴露的成骨细胞中观察到环氧合酶(COX)的产生增加。我们相信，目前的结果提供了有用的信息，支持先前临床报告的结果，即吸烟者的牙周治疗效果不如不吸烟者。

In the present study, we examined the various responses to cadmium (Cd) exposure of cells using human gingival epithelial cells, human gingival fibroblasts, human femur osteoblasts, and a commercial human osteoblast kit. The response to cadmium was different depending on the type of cell, and there were also differences in the cell type and concentration of cytokines induced by cadmium exposure. Based on the above results, it is concluded that the periodontal tissue of smokers is damaged by Cd present in tobacco. Also, increased production of cyclooxygenase (COX) was observed in osteoblasts exposed to Cd. We believe the present results provide useful information that supports the findings of previous clinical reports of an inferior periodontal therapeutic effect in smokers compared to nonsmokers.