Analysis on roles of immune modulating cytokines for strategic development of molecular therapeutics for age-related macular degeneration

我们分析了眼内炎性细胞因子水平与息肉样脉络膜血管病变（PCV）之间的关系，PCV是年龄相关性黄斑变性（ARMD）的一种主要形式，发现IL-23、VEGF和IL-4的升高提供了显著的高风险。为了进一步了解脉络膜新生血管（CNV）的分子病理学，我们还分析了近视脉络膜新生血管患者的细胞因子水平。IL-10为近视CNV提供了显著的高风险。为了了解CNV的炎症方面，采用小鼠激光诱导脉络膜新生血管模型。目前，我们对小鼠CNV模型的分析已经通过对转基因小鼠品系的信号传导分析，确定了ARMD的候选靶标信号分子

We analyzed the relationship between the levels of intraocular inflammatory cytokines and polypoidal choroidal vasculopathy (PCV), a major form of age related macular degeneration (ARMD), and found a significantly high risk was provided by elevation of IL-23, VEGF, and IL-4. To further understand molecular pathology of choroidal neovascularization (CNV), we also analyzed cytokine levels of myopic CNV patients. IL-10 provided a significantly high risk for myopic CNV. To understand inflammatory aspect of CNV, murine laser induced choroidal neovascularization model was used. Currently, our analysis on the mouse CNV model has identified the candidate target signaling molecule for ARMD using analysis of transgenic mouse strains for signaling of the molecule