Development of the effective bone augmentation using intracellular transfection of anti-apoptosis protein HSP27

在本研究中，我们评估了一种抗凋亡蛋白HSP27在移植细胞中的应用，以探索一种新的细胞移植方法。HSP27的过度表达不影响成骨细胞的增殖和矿化能力，但HSP27的过度表达可减少细胞的凋亡。此外，在细胞移植初期，移植细胞的凋亡也受到抑制，表达增殖标记物的细胞数量增加。

In the present study, to explore a new way of cell transplantation for bone augmentation, we evaluate the application of HSP27, an anti-apoptotic protein to the transplanted cell. The over expression of HSP27 did not affect the cell proliferation and mineralization ability of osteoblast, however, apoptosis was diminished by the over expression of HSP27. Furthermore, transplanted cell apoptosis was also inhibited and proliferation marker expressing cells were increased at the initial stage of cell transplantation.