Role of circadian clocks in allergic asthma

本研究的目的是解决生物钟在过敏性哮喘的症状发展和病情揭示中的作用，倡导通过昼夜节律控制来防治过敏性哮喘的新途径。在野生型小鼠中，通过对不同时间进行致敏来接受条件的差异。然而，在关键时钟基因Clock突变小鼠中，条件的差异是不被接受的。此外，还发现Toll样受体(TLR)4在野生型小鼠骨髓来源的树突状细胞(BMDC)上的表达受生物钟控制。这些结果表明，过敏性哮喘的发生依赖于昼夜节律控制的树突状细胞上TLR4的昼夜变化。

The purpose of this research is to solve the role which the biological clock plays in development of symptoms and condition revelation of allergic asthma and to advocate the new approach to prevention/medical treatment of the allergic asthma by circadian clocks control. In the wild-type mouse, the difference in condition was accepted by carrying out sensitization to different time. However, the difference in condition was not accepted in Clock, a key clock gene, mutant mouse. In addition, it foundout that revelation of Toll-like receptor (TLR) 4 on wild-type mice origin bone marrow-derived dendritic cell (BMDC) was controlled by a biological clock. These results suggest that the onset of allergic asthma was dependent on circadian change of TLR4 on dendritic cells controlled by the circadian clock.