Increased expression of aryl hydrocarbon receptor in clear cell renal cell carcinoma and infiltrating lymphocytes: Implications for cancer invasion, prognosis and tumor immunity

肾癌组织中AhR与吸烟史、性别、组织学分级显著相关。AhR阳性TIL的数量与组织学分级和病理T分期显著相关。肿瘤组织中T细胞明显多于B细胞。在预后不良的患者中，辅助性T细胞的数量明显高于细胞毒性T细胞。癌旁组织中AhR阳性的TIL和调节性T细胞的浸润明显多于癌组织。TIL中AhR表达是无进展生存期的显著预测因子。多因素分析显示癌细胞AhR是影响无进展生存期和疾病特异性生存期的独立预后因素，提示AhR可能参与肿瘤免疫。

AhR in RCC was significantly associated with the smoking history, gender and histological grade. The number of AhR-positive TIL was significantly associated with histological grade and pathological T stage. In tumor tissues, the number of T cell was significantly higher than that of B cell. In the patients who have poor prognosis, the number of helper T cell was significantly higher than that of cytotoxic T cell. Furthermore, in those patients AhR-positive TIL and regulatory T cell more infiltrated in tumor adjacent tissues than in tumor tissues. The AhR expression in TIL was a significant predictor for progression free survival. A multivariate analysis revealed that AhR in cancer cells was an independent prognostic factor for the progression free survival and disease specific survival.These results suggest that AhR may be involved in tumor immunity.