Epigenome information profiling for molecular basis on seed epigetics

基因组DNA和组蛋白修饰，如甲基化、乙酰化和磷酸化，编码控制细胞功能的表观遗传信息，如基因表达和调控。这种信息独立于核酸序列，并通过细胞分裂和世代来传递和维持。然而，植物之间的表观遗传动态，特别是在个体籽粒水平上的干种子到其发育期的动力学还没有得到很好的描述。在这项研究中，开发了一个实验模型系统来分析转基因和野生型水稻基因组DNA甲基化和组蛋白修饰的模式。所得数据采用多变量统计方法进行分析。第一次，表观遗传信息图谱显示，转基因种子可能与野生型种子不同。

Genomic DNA and histone modifications, such as methylation, acetylation and phosphorylation, code for epigenetic information which control cellular function such as gene expression and regulation. This information is independent of the nucleic acid sequence, and is transmitted and maintained through cell division and generations. However, the epigenetic dynamisms among plants, especially dry seed to its germinal stage at individual grain level, have not been well characterized. In this study, an experimental model system was developed to analyze pattern of the genomic DNA methylation and histone modifications in genetically modified and wild-type rice. The obtained data were analyzed using multivariable statistical method. For the first time, the epigenetic information profiling showed that the genetically modified seed may differ from the wild-type seed.