Tailored silver nanoparticles (NPs) in biological environments: Interactions with biomolecules and cells (nano.ag)

银纳米颗粒代表了具有最高商业影响的纳米颗粒类别，由于其杀菌潜力，被用于消费品、纺织品和医疗设备。我们将从不同的层面研究自行合成和表征的银纳米粒子的生物作用：它们与生物分子的相互作用，它们进入细胞的过程，它们的生物作用机制，银离子在释放时的溶解，以及它们摄取和内化后在细胞中的归宿。这些研究将在不同的表面功能化类型和银纳米颗粒的尺寸下进行。作为对比，金纳米颗粒作为一种生物惰性材料，具有相同的表面官能化和大小，将用同样的方法进行测试。

Silver nanoparticles represent the class of nanoparticles with the highest commercial impact, being used in consumer commodities, textiles and medical equipment due to their bactericidal potential. The biological action of self-synthesized and thoroughly characterized silver nanoparticles will be investigated at various levels: Their interaction with biomolecules, their entrance into cells, the mechanism of their biological action, the dissolution under release of silver ions, and their fate in the cell after uptake and internalization. These investigations will be carried out under variation of the kind of surface functionalization and the size of the silver nanoparticles. For comparison, gold nanoparticles as a biologically inert material with the same surface functionalization and size will be tested by the same methods.