Entwicklung, Konstruktion und Bau einer auf maximalen Ionentransfer optimierten AP-Ionisationsquelle zur massenspektrometrischen Analyse

本提案将后续工作描述为伍珀塔尔大学的分析、物理化学和理论化学三个研究小组以及亚琛皇家理工大学喷气推进和涡轮机械研究所非常成功的联合工作的延续。在DFG的资助下，过去三年开展的工作在对大气压力电离源的更基本的了解和确定性发展方面取得了一些重大成就。高质量的计算流体力学模拟起到了举足轻重的作用，这些模拟被成功地用作离子轨迹计算的输入参数。一些已经投入使用的新一代原料药来源被用于例如多环芳烃的分析。本提案的主要目标是对过去三年收集的数据和知识库进行严格的延续、应用和外推。目前的联合研究工作将集中在层流低流量和主动控制的高流量API源的开发和分析应用上。这两种新颖的设计被认为是最强大的API源类型。初步设计阶段的初步来源已经证明，在灵敏度、稳定性和时间分辨率方面，明显优于商业上可获得的传统API来源。

The present proposal describes follow-up work as a continuation of the very successful joint effort of the three research groups Analytical, Physical and Theoretical Chemistry of the University Wuppertal, and the Institute of Jet Propulsion and Turbomachinery of the RWTH Aachen University. The work performed over the past three years, funded by the DFG, resulted in a number of major achievements with regard to a more fundamental understanding and deterministic development of atmospheric pressure ionization (API) sources. A pivotal role played high-quality computational fluid dynamics simulations, which were successfully used as input parameters for ion trajectory calculations. A couple of new generation API sources already operational are used in e.g. the analysis of polycyclic aromatic hydrocarbons. The main goal of the present proposal is a rigorous continuation, application, and extrapolation of the data and knowledge base assembled in the preceding three years. The present joint research efforts will focus on the development and analytical application of laminar low-flow and actively controlled high-flow API sources. These two novel designs were identified as the most powerful API source types. Preliminary sources at the initial design stage have already proven to be clearly superior to commercially available conventional API sources with regard to sensitivity, stability, and temporal resolution.