ANGIOGENESIS AND MONOCLONAL ANTIBODY UPTAKE IN MICROMETASTASES OF THE LIVER

为探讨微转移瘤血管生成与单克隆抗体（mAb）摄取之间的关系，本研究采用人结肠癌细胞（HT-29）建立裸鼠肝微转移瘤模型，并对该模型中的血管生成和mAb（H-15）摄取进行分析。在大小在300*600 μ m之间的微转移中，发现大量的血管生成，并且在较新的血管周围鉴定出高的mAb积聚。这一信息是非常有用的，在辅助设置进行放射免疫治疗的临床试验。

To determine the relationship between angiogenesis and monoclonal antibody (mAb) uptake in micrometastases, we made a model of hepatic micrometastases after splenic injection of human colon cancer cell (HT-29) in nude mice, and analyze the angiogenesis and mAb (H-15) uptake in the model. In micrometastases which size were between 300*600 mum, a plenty of angiogenesis was found and high accumulation of mAb was identified around newer vessels. This information is very useful to conduct clinical trials of radioimmunotherapy in adjuvant setting.