Omics analysis of HIV during synthetic opioid exposure

摘要 2019年12月，武汉、中国、北京等地发生不明原因肺炎疫情。 病原体被鉴定为一种新的冠状病毒，命名为严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)。此外，美国正处于一场主要的阿片类药物流行之中，这主要归因于合成的 阿片类药物，如芬太尼和SARS-CoV-2大流行正在世界上最近发生的一些地区发生 据报道，由于阿片类药物危机，艾滋病毒感染人数有所增加。随着SARS-CoV-2的大流行，有 对阿片类药物危机恶化的主要关切。患有毒瘾的人特别是 容易受到SARS-CoV-2感染增加和更严重的疾病的影响。许多阿片类药物是 也与免疫抑制和增强的病毒致病机制有关。因此，基础研究 病毒-病毒和病毒-阿片类药物的相互作用对于了解SARS-CoV-2对其他相关疾病的影响是至关重要的 病态条件，并开发强有力的治疗选择，以限制病毒感染和发病机制 高危人群。

Abstract In December 2019, an outbreak of pneumonia of unknown cause occurred in Wuhan, China, and the causative agent was identified as a novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Additionally, the US is in the midst of a major opioid epidemic largely attributed to synthetic opioids such as fentanyl, and the SARS-CoV-2 pandemic is occurring in parts of the world where recent increases in HIV due to the opioid crisis have been reported. With the SARS-CoV-2 pandemic, there are major concerns about worsening of the opioid crisis. People suffering from addiction are particularly vulnerable to increased infection with SARS-CoV-2 and more advanced disease severity. Many opioids are also associated with immune suppression and enhanced viral pathogenesis. Thus, foundational research on virus-virus and virus-opioid interactions is essential for understanding the impact of SARS-CoV-2 on other co- morbid conditions and for developing robust therapeutic options for limiting viral infection and pathogenesis in high-risk populations.