Diet Patterns and Alzheimer Disease and Other Dementias

主要研究者/项目负责人（最后，第一，中间）：Morris，Martha克莱尔 这个R 01申请，题为“饮食模式和阿尔茨海默氏病和其他痴呆症 神经病理学”是针对PAR-15-356的修订提交资料。到2050年， 预计将有1350万美国人患有AD，成本为1.1万亿美元。目前还 没有治愈AD的方法，也没有有效的治疗方法。因此，预防性治疗对于阻止 公共卫生危机。据估计，将痴呆症的发病时间推迟5年将降低成本。 和患病率减半。生活方式干预是一个很好的战略，人口- 广泛的影响。有相当多的流行病学证据将饮食与AD预防联系起来， 通过疾病病因学中的潜在生物学机制来确定个体营养素。此外， 许多AD风险因素都有饮食基础。包括DASH在内的饮食模式 地中海饮食和这些饮食的混合体称为MIND（地中海-DASH饮食 神经退行性延迟的干预）与认知下降的速度较慢有关， 降低AD发病率。到目前为止，还没有一项研究将饮食模式与 阿尔茨海默病脑神经病理学或与痴呆相关的其他神经病理学。的 临床神经病理学队列研究，拉什记忆和衰老项目提供了独特的 有机会调查这些健康的饮食模式与脑神经病理学的关系， 大脑健康在600名研究参与者中获得的广泛的临床和饮食数据 尸检数据将允许前所未有的检查饮食模式的关系， 与AD痴呆相关的神经病理学（淀粉样斑块、神经纤维缠结和 CERAD、Braak和NIA Reagan评分）、血管性痴呆（大梗塞和小梗塞，TDP-43， 动脉粥样硬化、动脉硬化、脑淀粉样血管病），其它痴呆（路易体， 海马硬化）和突触前蛋白，这是大脑健康和认知储备的一种衡量标准。 这项研究还将研究脑神经病理学和神经系统疾病的潜在介导作用。 突触前蛋白对MIND、DASH和地中海饮食模式的影响 认知功能下降和临床痴呆。这项研究将通过识别 饮食与认知能力下降、AD和 其他痴呆症 PHS 398/2590（2004年9月修订，2006年4月重新印发）

Principal Investigator/Program Director (Last, First, Middle): Morris, Martha Clare This R01 application, entitled “Diet Patterns and Alzheimer's Disease and Other Dementia Neuropathologies” is a revised submission in response to PAR-15-356. By the year 2050 it is projected that there will be 13.5 million Americans with AD at a cost of $1.1 trillion. Currently there is no cure for AD and no effective treatments. Preventive therapies are thus crucial for heading off a public health crisis. It is estimated that delaying dementia onset by just 5 years will reduce the cost and prevalence of the disease by half. Lifestyle interventions are an excellent strategy for population- wide impact. There is considerable epidemiological evidence linking diet to AD prevention, supported by underlying biologic mechanisms in the disease etiology for individual nutrients. In addition, a large number of AD risk factors have a demonstrated dietary basis. Dietary patterns including the DASH and Mediterranean diets and a hybrid of these diets called MIND (Mediterranean-DASH Diet Intervention for Neurodegenerative Delay) have been related to slower rates of cognitive decline and decreased incidence of AD. To date there has not been a study that has related dietary patterns to Alzheimer disease brain neuropathology or other neuropathologies associated with dementia. The clinical-neuropathologic cohort study, the Rush Memory and Aging Project affords the unique opportunity to investigate the relation of these healthy diet patterns to brain neuropathologies and to brain health. The extensive clinical and dietary data obtained among 600 hundred study participants with autopsy data will allow for unprecedented examination of diet pattern relations to multiple neuropathologies associated with AD dementia (amyloid plaques, neurofibrillary tangles, and CERAD, Braak, and NIA Reagan scores), vascular dementia (macro- and micro-infarcts, TDP-43, atherosclerosis, arteriosclerosis, cerebral amyloid angiopathy), other dementias (Lewy bodies, hippocampal sclerosis) and presynaptic proteins, a measure of brain health and cognitive reserve. The study will also examine the potential mediating roles of brain neuropathologies and of presynaptic proteins on the MIND, DASH, and Mediterranean dietary pattern associations with decline in cognitive function and clinical dementia. The study will advance the science by identifying the neuropathologic biomechanisms underlying dietary relationships to cognitive decline, AD and other dementias. PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Continuation Format Page