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T follicular helper (Tfh) CD4+ T cell, germinal center, and antibody response dysfunction in human recurrent tonsillitis

T follicular helper (Tfh) CD4+ T cell, germinal center, and antibody response dysfunction in human recurrent tonsillitis
人复发性扁桃体炎中滤泡辅助性 T (Tfh) CD4 T 细胞、生发中心和抗体反应功能障碍
批准号：
10169568
负责人：
Shane P Crotty
金额：
$38.62万
依托单位：
LA JOLLA INSTITUTE FOR IMMUNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
项目状态：
已结题
起止时间：
2020-05-26 至 2021-02-28
来源：
https://reporter.nih.gov/project-details/10169568
关键词：
2019-nCoVAntibody ResponseAntigensB-LymphocytesBacteriaBiologyBronchoalveolar LavageCD4 Positive T LymphocytesCD8-Positive T-LymphocytesCOVID-19COVID-19 vaccineCellsDevelopmentDiseaseEpitopesFunctional disorderHelper-Inducer T-LymphocyteHumanImmune responseImmunologicsImpairmentInfectionInterventionKnowledgeLungMeasuresMedicalPatientsPeptidesPeripheral Blood Mononuclear CellPhenotypeRecurrenceResolutionSeverity of illnessStructure of germinal center of lymph nodeT cell responseT-LymphocyteT-Lymphocyte EpitopesTechniquesTherapeuticTonsillitisVaccinesViruscost effectivecytokinein vivoinnovationpandemic diseasepathogenresponsetherapy development

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中文摘要
翻译
整体组件 COVID19是一种严重的持续大流行。我们对这种疾病的免疫反应缺乏了解， 这既损害了适当疗法的发展，也损害了疫苗的开发。疫苗是成本最高的疫苗之一 有效且非常成功的医疗干预。这些疫苗大多依赖于CD4T+细胞 以及他们对B细胞的帮助。在过去的一段时间里，我们开发了多种新技术来研究人类的CD4+T细胞 几年来，一直在我们的LJI CCHI实施。这里提出的补充建议将有助于 快速和积极地了解人类对SARS-CoV2的T细胞反应，这可能是 帮助开发柯萨奇病毒19的治疗方法和疫苗。
英文摘要
Overall Component COVID19 is a severe ongoing pandemic. Our understanding of the immune response to this disease is lacking, which impairs both the development of proper therapeutics and a vaccine. Vaccines are one of the most cost effective and extraordinarily successful medical interventions. Most of those vaccines depend on CD4 T+ cells and their help to B cells. We have developed multiple new techniques to study human CD4+ T cells over the past several years, which have have been implementing in our LJI CCHI. The supplement proposed here will facilitate rapid and vigorous pursuit of an understanding of the T cell responses to SARS-CoV2 in humans, which may help in the development of treatments and vaccines for COVID19.
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Immune engineering of optimized sequential immunization strategies for HIV vaccines
Immune engineering of optimized sequential immunization strategies for HIV vaccines
T follicular helper (Tfh) CD4+ T cell, germinal center, and antibody response dysfunction in human recurrent tonsillitis
  • 批准号：
    10304742
  • 项目类别：
  • 资助金额：
    $126.39万
  • 财政年份：
    2020
  • 负责人：
    Shane P Crotty
  • 依托单位：
    LA JOLLA INSTITUTE FOR IMMUNOLOGY
Administrative Core
  • 批准号：
    10591866
  • 项目类别：
  • 资助金额：
    $6.88万
  • 财政年份：
    2020
  • 负责人：
    Shane P Crotty
  • 依托单位：
    UNIVERSITY OF FLORIDA
海外基金