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Conduct of studies to evaluate the toxic potential of N-BUTYLBENZENE SULFONAMIDE (NBBS) in laboratory animals for the National Toxicology Program (NTP)

Conduct of studies to evaluate the toxic potential of N-BUTYLBENZENE SULFONAMIDE (NBBS) in laboratory animals for the National Toxicology Program (NTP)
为国家毒理学计划 (NTP) 开展研究,评估正丁基苯磺酰胺 (NBBS) 对实验动物的潜在毒性
批准号:
10213569
负责人:
BARNEY SPARROW
金额:
$80.0万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
已结题
起止时间:
2017-09-26 至 2020-09-25

项目摘要

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中文摘要
翻译
本项目的目标是评估NBBS在投喂饲料中暴露后的亚慢性、生殖、发育和神经行为毒性。这些研究处于病理学/数据分析/报告阶段。NBBS应用广泛,但其毒性数据库有限。它是一种常见的增塑剂和高产量化学品。有限的毒性数据表明存在多个靶点。NTP研究将为各种终点提供有价值的数据,以全面评估潜在危害。 关键词:毒性,神经行为,发育,生殖,投喂,N-丁基苯磺酰胺。
英文摘要
The goal of this project is to evaluate the subchronic, reproductive, developmental and neurobehavioral toxicity of NBBS following exposure in dosed feed. These studies are in the pathology/data analysis/reporting phase. There is extensive used of NBBS and its toxicity database is limited. It is a common plasticizer and high production volume chemical. The limited toxicity data suggest multiple targets. The NTP studies will provide valuable data to on a wide variety of endpoints to provide a thorough evaluation of potential hazards. Keywords: toxicity, neurobehavioral, developmental, reproductive, dosed feed, N-BUTYLBENZENE SULFONAMIDE.
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Production of TempOSeq data for the DrugMatrix reference library
  • 批准号:
    10710454
  • 项目类别:
  • 资助金额:
    $110.04万
  • 财政年份:
    2017
  • 负责人:
    BARNEY SPARROW
  • 依托单位:
Systematic Evaluation of the Application of Zebrafish in Toxicology (SEAZIT) Phase 2
  • 批准号:
    10213572
  • 项目类别:
  • 资助金额:
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  • 财政年份:
    2017
  • 负责人:
    BARNEY SPARROW
  • 依托单位:
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  • 批准号:
    10700772
  • 项目类别:
  • 资助金额:
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  • 财政年份:
    2017
  • 负责人:
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  • 依托单位:
海外基金