Control of immune recognition and response by microbial metabolites

该项目旨在研究微生物代谢产物的免疫识别，并开发控制免疫反应的试剂。化学合成将被用于开发非传统T细胞的新抗原，以及第一批可溶的糖脂敏感免疫受体的激动剂和拮抗剂。预期的结果包括发现新的免疫效应器，拓宽我们对免疫系统可以感知的小分子谱系的知识，以及开发促进或抑制免疫反应的化学方法。主要好处包括化学生物学方面的研究培训、加强国际联系以及对免疫识别和反应的化学基础的基本见解。

This project aims to study immune recognition of microbial metabolites and develop reagents to control immune responses. Chemical synthesis will be used to develop new antigens for unconventional T cells and the first soluble agonists and antagonists of a glycolipid-sensing immune receptor. Expected outcomes include the discovery of new immune effectors, broadening our knowledge of the repertoire of small molecules that can be sensed by the immune system, and developing chemical approaches to promote or dampen immune responses. Major benefits include research training in chemical biology, strengthened international linkages and fundamental insights into the chemical basis of immune recognition and response.