Dissecting a major sulfur cycling pathway: sulfoglycolysis

该项目将阐明巯基糖酵解的分子细节，这是一组代谢途径，通过这些代谢途径，含硫糖巯基藜糖被分解代谢。该项目将采用综合代谢组学、化学、生物化学和结构方法来分析各种硫糖酵解生物如何降解硫喹诺糖。该项目将提供对这一主要生化途径的更深入了解，并开发新的化学和代谢方法来操纵环境中的硫循环。收益将包括新发现的蛋白质的生物技术应用，以及减少我们对农业肥料依赖的可持续方法。

This project will elucidate the molecular details of sulfoglycolysis, a group of metabolic pathways through which the sulfur-containing sugar sulfoquinovose is catabolized. The project will employ an integrated metabolomic, chemical, biochemical and structural approach to dissect how various sulfoglycolytic organisms degrade sulfoquinovose. This project will deliver a deeper understanding of this major biochemical pathway and develop new chemical and metabolic approaches to manipulate sulfur cycling in the environment. Benefits will include biotechnology applications of newly discovered proteins, and sustainable approaches to reduce our dependence on agricultural fertilisers.