Core-005

细胞和组织成像核心提供先进的细胞和组织成像技术、服务和 科学咨询。核心促进科学合作，提高南加州大学诺里斯分校的能力 成员进行创新的癌症研究。自15年前成立以来，细胞和组织成像 CORE不断获得NCI CCSG的批准和资助。该设施一直由能干的 创始董事David Hinton博士，并由技术总监Ernesto Barron监督，两人都 在显微镜领域有30多年的经验。2014年，斯科特·弗雷泽博士，国际公认的 成像技术创新者，从加州理工大学应聘到南加州大学。其目标是为国家提供 通过该设施在成像技术方面的领先地位，弗雷泽博士作为联席主任加入了欣顿博士的行列 2015年1月。 细胞和组织成像核心使癌症中心成员能够轻松访问广泛的 一系列复杂的成像设备和服务，包括激光扫描共焦/多光子 显微镜，活细胞旋转盘共聚焦成像，透射电子显微镜，扫描 电子显微镜(SEM)、数字光学和荧光显微镜、荧光和明场激光 捕获显微解剖、薄切片、冷冻切片和包埋技术以及计算机辅助技术 图形。为了提供最先进的技术，Core正在添加新的仪器：一场风暴 超分辨率单分子成像荧光显微镜，双光子SPIM光片成像仪， Flip Trap成像示波器和一种新型的高光谱相量成像(HPI)仪器。作为其使命的一部分 为了帮助成员了解核心资源如何推动他们的研究，核心资源有一个积极的教育和 培训计划，通过该计划，它建议和指导南加州大学诺里斯调查人员的新方法和 增强其细胞和组织成像能力的方案。 在2013-2014财年，来自南加州大学诺里斯研究项目的36名癌症中心成员使用了Core， 这既反映了服务的质量，也反映了继续教育和培训努力的价值。在 2015年秋季，核心将搬迁到南加州大学诺里斯·托平塔的翻新空间。更接近于 大多数用户和总体可见性的提高应该会导致下一个项目期的使用量增加。

The Cell and Tissue Imaging Core provides advanced cell and tissue imaging technology, services, and scientific consultation. The Core facilitates scientific collaboration and advances the ability of USC Norris members to conduct innovative cancer research. Since its founding 15 years ago, the Cell and Tissue Imaging Core has been continuously approved and funded by the NCI CCSG. The facility has been ably led by the founding Director, Dr. David Hinton, and supervised by Technical Director, Ernesto Barron, both of whom have over 30 years of experience in the field of microscopy. In 2014, Dr. Scott Fraser, an internationally recognized innovator in imaging technology, was recruited to USC from Caltech. With the goal of providing national leadership in imaging technology through the facility, Dr. Fraser joined Dr. Hinton as Co-Director effective January 2015. The Cell and Tissue Imaging Core makes it possible for Cancer Center members to easily access a wide range of sophisticated imaging equipment and services, including laser scanning confocal/multiphoton microscopy, live cell spinning disk confocal imaging, transmission electron microscopy (TEM), scanning electron microscopy (SEM), digital light and fluorescence microscopy, fluorescence and bright field laser capture microdissection, thin sectioning, cryo-sectioning and embedding techniques, and computer aided graphics. In its effort to provide state-of-the-art technology, the Core is adding new instrumentation: a STORM super-resolution single-molecule imaging fluorescence microscope, a Two-Photon SPIM light sheet imager, a Flip Trap imaging scope, and a novel Hyperspectral Phasor Imaging (HPI) instrument. As a part of its mission to help members learn how Core resources can advance their research, the Core has an active education and training program through which it advises and instructs USC Norris investigators in novel methodologies and protocols to enhance their cell and tissue imaging capability. In FY 2013-2014, the Core was used by 36 Cancer Center members from six USC Norris Research Programs, which reflects both the quality of the service and the value of continued education and training efforts. In the fall of 2015, the Core will relocate to renovated space in USC Norris Topping Tower. Closer proximity to the majority of users and increased overall visibility should result in increased usage in the next project period.