Cellular & Tissue Imaging

摘要：细胞和组织成像核心 先进的细胞显微镜是生物学研究的有力工具， 糖尿病的发病机制和治疗的研究。成像技术在过去几年中发展迅速， 在过去的十年里，分辨率、灵敏度和速度都有了很大的提高， 新的机会，研究过程跨越许多数量级和实时在活细胞和 动物与此同时，越来越复杂的设备的成本是巨大的， 有效地使用、维护和开发这种设备在大多数实验室中并不常见。因此有 这些强大工具的可用性与调查人员获取和使用这些工具的能力之间存在巨大差距 他们效率。为了满足这些需求，华盛顿大学细胞和组织成像中心 （WUCCI）成立于2015年。在运作的第一年，WUCCI为146项研究提供了服务。 实验室，包括40糖尿病研究中心（DRC）成员。DRC成员的反馈表明， 对先进的显微成像和图像分析的需求是巨大的，并将继续增长。 因此，DRC提出了一个新的细胞和组织成像核心，以利用重要的机构 投资于新成立的WUCCI。 细胞和组织成像核心的总体目标是提供一种综合方法， 糖尿病相关细胞和组织的结构和动力学行为。通过提供获取和技术 支持使用先进的细胞显微镜工具，细胞和组织成像核心将加速 加快糖尿病研究的步伐，扩大研究范围，提高研究效率。在过去的六个月里，刚果民主共和国 行政核心设立了一个奖学金计划，以鼓励DRC成员使用WUCCI， 与糖尿病有关的研究和21个研究实验室已经从奖学金中受益。 拟议的细胞和组织成像核心服务满足众多研究者的独特要求 在广泛的基础和转化研究，并将吸引新的研究人员进入糖尿病研究。 重要的是，用户将受益于核心董事的深入糖尿病和技术专业知识， 技术人员在为实验设计和数据解释进行咨询时所花费的时间。细胞和 组织成像核心将提供必要的服务，这将使和加速DRC中心的研究 在下一个融资周期中。

ABSTRACT: Cell and Tissue Imaging Core Advanced cellular microscopy is a powerful tool for biological research and has an important role to play in the study of the pathogenesis and treatment of diabetes mellitus. Imaging technology has evolved rapidly over the last decade leading to improvements in resolution, sensitivity and speed which have created fundamentally new opportunities for studying processes across many orders of magnitude and in real-time in living cells and animals. At the same time, the costs of increasingly sophisticated equipment are substantial and the expertise to efficiently use, maintain, and develop this equipment is not common in most labs. Therefore, there is a significant gap between the availability of these powerful tools and the ability of investigators to access and use them efficiently. To address these needs, the Washington University Center for Cellular and Tissue Imaging (WUCCI) was established in 2015. During its first year of operations, the WUCCI served 146 research laboratories, including 40 Diabetes Research Center (DRC) members. Feedback from DRC members indicates that needs for advanced microscopic imaging and image analysis are substantial and will continue to grow. Therefore, the DRC is proposing a new Cell and Tissue Imaging Core to leverage the significant institutional investment in the newly created WUCCI. The overall objective of the Cell and Tissue Imaging Core is to provide an integrated approach to investigate the structure and dynamic behavior of diabetes-related cells and tissues. By providing access to and technical support in using advanced cellular microscopy tools, the Cell and Tissue Imaging Core will accelerate the pace, expand the scope, and improve efficiency of diabetes research. During the past 6 months, the DRC Administrative Core established a scholarship program to encourage DRC member use of WUCCI for diabetes-related studies, and 21 investigator laboratories have already benefitted from scholarship awards. The proposed Cell and Tissue Imaging Core services meet the unique requirements of numerous investigators over a wide range of basic and translational research and will attract new investigators into diabetes research. Importantly the users will benefit from the in-depth diabetes and technical expertise of the Core directors and technical staff in the time spent in consultation for experimental design and interpretation of data. The Cell and Tissue Imaging Core will provide essential services that will enable and accelerate the research of DRC center members throughout the next funding cycle.