Core D-Neuropathology Core

项目摘要--神经病理学核心(核心D) UCI ADRC神经病理(NP)核心提供尸检、诊断和生物信息库服务 UCI ADRC的三个队列-统一数据集(UDS)、90+和唐氏综合症-涵盖了广泛的 年龄和阿尔茨海默病易感性的范围。NP核心的首要目标是支持教育， 与ADRC的其他核心和合作，推广和研究AD及相关疾病(ADRD) ADRD研究人员致力于“识别、量化和验证影响终生AD风险的因素”。 自成立以来，NP Core已经收集和维护了相当大的优质银行 生物菌素，已广泛分布到NCRAD和联邦资助的地方、国家和 国际反兴奋剂机构调查人员和财团。核心运营不断得到增强，指标 的核心业绩表现强劲。为了扩大其能力，三名新教员加入了NP核心，其中包括一名 同时也是REC学员的神经病理学家(Mari Perez-Rosendahl)。与其他UCI ADRC一起 核心，NP核心提出六个目标，通过以下方式加强其诊断、教育和研究功能 协作、创新和教育：1)提供准确、及时、全面和标准化的 对UDS受试者和特殊人群的尸检和诊断报告，包括 与IPSC Core合作，增加了对选定病例的尸检皮肤收集；2)收获， 处理、存储、编目和分发高质量的脑组织和生物样品给UCI的ADRD研究人员 此外，与DMS和Biomarker核心在其数据管理和生物监测方面进行合作 利用功能；3)采用新的分析方法，使UCI的新的小胶质细胞研究成为可能 阿尔茨海默病新的小胶质细胞生物学前沿的研究人员；4)将整个幻灯片成像(WSI)结合到 促进诊断、研究和教育，包括与统一通信范围内的WSI建立接口 网络和UCI人工智能(AI)中心；5)支持新的ADRD研究和推广 与其他UCI ADRC核心和其他ADRC合作，包括涉及尸检MRI的新研究， 清除脑组织的光片显微镜，以及WSIS的人工智能研究；以及6)贡献独特的专业知识 对包括佩雷斯博士在内的下一代AD临床医生和研究人员的教育和培训- 罗森达尔，神经病理学家和REC导师。

PROJECT SUMMARY – NEUROPATHOLOGY CORE (CORE D) The UCI ADRC Neuropathology (NP) Core provides autopsy, diagnostic, and biorepository services for the three cohorts of the UCI ADRC - Uniform Data Set (UDS), 90+, and Down syndrome - which span a broad range of ages and susceptibilities to AD. The overarching goal of the NP Core is to support education, outreach, and research on AD and related disorders (ADRD) in collaboration with other ADRC cores and ADRD researchers to “identify, quantify, and validate factors that influence the risk of AD across the lifespan.” Since its inception, the NP Core has collected and maintained a considerable bank of high-quality biospecimens, which have been distributed broadly to NCRAD and federally-funded local, national, and international ADRD investigators and consortia. Core operations have been continually enhanced, and metrics of core performance are strong. To expand its capacity, three new faculty have joined the NP Core, including a neuropathologist who is also a REC mentee (Mari Perez-Rosendahl). Together with the other UCI ADRC Cores, the NP Core proposes six Aims to enhance its diagnostic, education, and research functions via collaboration, innovation, and education: 1) Provide accurate, timely, comprehensive, and standardized postmortem examinations and diagnostic reports on UDS subjects and special populations, including the addition of postmortem skin collection on selected cases in collaboration with the iPSC Core; 2) Harvest, process, store, catalog, and distribute high-quality brain tissue and biospecimens to ADRD researchers at UCI and beyond, collaborating with the DMS and Biomarker Cores in its data management and biospecimen utilization functions; 3) Incorporate new analysis methods to enable novel microglial studies by UCI investigators at the cutting-edge of a new microglial biology in AD; 4) Incorporate whole slide imaging (WSI) to facilitate diagnoses, research, and education, including the establishment of interfaces with a UC-wide WSI network and UCI artificial intelligence (AI) center; 5) Support novel ADRD research and outreach in collaboration with other UCI ADRC Cores and other ADRCs, including new studies involving postmortem MRI, light sheet microscopy of cleared brain tissues, and AI studies of WSIs; and 6) Contribute unique expertise to the education and training of the next generation of AD clinicians and researchers, including Dr. Perez- Rosendahl, neuropathologist and REC mentee.