Center for Environmental Genetics

总体--项目摘要 环境遗传学中心(CEG)的愿景是成为基因环境领域的全球领导者 互动(GxE)研究和翻译。它的使命是进行创新的、多学科的GxE研究 并在国内和全球通过社区赋权将发现转化为疾病预防。 该中心是GxE研究的先驱。我们在当前的筹资周期中取得了显著进展， 促进对表观遗传学作为遗传学和环境之间的桥梁的理解的新举措； 进一步确定易感窗口；确定复杂疾病早期起源的机制； 以及发现基因变异对疾病易感性的影响。在即将到来的基金周期中，我们将继续 基于机制的GxE知识和减少环境的翻译进展的陡峭轨迹 疾病。我们的乐观前景是基于我们拥有的宝贵的智力和物理中心资源 在过去的25年里发展起来的。首先，我们建立了十个高度重视的队列，有利于环境 在CEG内部或与其他NIEHS-EHSC中心共享的健康科学(EHS)研究。第二，我们有 在高通量多组学研究方面建立了尖端技术和能力。第三，我们有 一些最先进的生物信息学方法和现代管道在数据分析中解锁力量 为了更好地理解复杂疾病背后的机制基础，我们对组学进行了深入研究。最后，我们有 通过由一位 该领域的思想领袖干部。我们的力量是巨大的，我们的资源源源不断，我们的凝聚力 支持强大的中心身份。展望新的融资周期，我们的未来目标如下：(1) 从区域队列扩展到国际队列，以进一步研究新出现的环境污染物；(2) 开发新的统计和生物信息学方法来确定疾病的个体和累积影响 暴露和混合物中化学物质的相互作用；(3)将我们的组学平台扩展到单细胞 转录组和表观基因组分析，线粒体基因组和表观基因组的询问和 元基因组学在微生物组研究中的应用；(4)实现GxE研究向精确化的潜力 以医学为基础的风险评估、预防和治疗；(5)尽量减少环境疾病和 通过与社区、卫生保健专业人员、 并加强我们对健康差距较大的弱势群体的关注。我们的 目标与NIEHS战略计划的11个目标非常一致。我们相信，我们将再次显著地 用新概念和新技术为EHS知识库做出贡献，并开发人力资本 通过训练。我们的努力将把环境暴露对大辛辛那提健康的影响降至最低， 在我们国家和全球范围内。

OVERALL – Project Summary The vision of the Center for Environmental Genetics (CEG) is to become a global leader in gene-environment interaction (GXE) research and translation. Its mission is to conduct innovative, multidisciplinary GXE research and translate discoveries to disease prevention via community empowerment, at home and around the globe. The Center is a pioneer in GXE research. We have made outstanding progress in the current funding cycle with new initiatives in advancing the understanding of epigenetics as a bridge between genetics and the environment; further defining windows of susceptibility; identifying mechanisms underlying early-origins of complex diseases; and discovering the impact of genetic variants on disease susceptibility. In the coming fund cycle, we will continue on a steep trajectory of progress in mechanism-based GXE knowledge and translation to reduce environment disease. Our optimistic outlook is based on the valuable intellectual and physical Center resources that we have developed over the past 25 years. First, we have built ten highly valued cohorts, conducive to environmental health sciences (EHS) research within the CEG or shared with other NIEHS-EHSC Centers. Second, we have established leading-edge technologies and capabilities in high-throughput multi-omics research. Third, we have some of the most advanced bioinformatics methods and modern pipelines in data analysis to unlock the power of omics for better understanding of the mechanistic basis underlying complex diseases. Finally, we have attracted incredible young talent ready to become the next-generation of EHS leaders through mentoring by a cadre of thought-leaders in the field. Our strength is immense, our resources run deep, and our cohesiveness supports a strong Center identity. Looking to our new funding cycle, we have the following future goals: (1) To expand from regional to international cohorts to further our study of emerging environmental contaminants; (2) To develop novel statistical and bioinformatics methods to identify the individual and cumulative effects of exposures and the interactions of chemicals in a mixture; (3) To extend our omics platform to single-cell transcriptome with epigenome analyses, interrogation of the mitochondrial genome and epigenome and applications of metagenomics to microbiome; (4) To realize the potential of GXE research towards precision medicine-based risk assessment, prevention, and therapies; (5) To minimize environmental disease and promote healthier living in clean environments through partnerships with communities, health care professionals, and policy-makers and to sharpen our focus on vulnerable populations with significant health disparities. Our goals are well-aligned with the eleven goals of the NIEHS Strategic Plan. We believe we again will significantly contribute to the EHS base of knowledge with new concepts and technologies, and develop human capital through training. Our efforts will minimize the impact of environmental exposures on health in Greater Cincinnati, in our nation and across the globe.