Caenorhabditis Intervention Testing Program - Data Coordination Center

项目摘要 与人类老龄化相关的健康挑战给我们的社会带来了巨大的损失。身体和认知能力的下降限制了老年人及其照顾者的生活质量。老龄化是癌症、糖尿病和神经退行性疾病的主要风险因素和可能原因，因此与衰弱性疾病的斗争是老龄化人口的共同健康负担。毫无疑问，促进健康的老龄化，延长对衰退的抵抗力，应该是当前医学研究的主要目标。为了研究健康衰老，简单的动物模型，如线虫C。已经对秀丽隐杆线虫进行了研究，提供了对基因和化学化合物干预的分子见解，这些基因和化学化合物干预可以调节可能在人类中起类似作用的保守衰老过程。拟议工作的目标是继续并扩大一个合作科学小组的努力，该小组涉及三个密切互动的实验室，他们协调测试药理干预措施，以延长线虫的健康衰老和促进长寿的能力。这个综合超级组的一个具体重点是测试有前途的药物对一组自然变异的小杆线虫属，这共同代表了广泛的遗传异质性在人群中。这个想法是，在不同人群中产生积极结果的治疗方法将增加在高等生物中有效的机会，并将被建议作为临床前小鼠研究和可能的未来人体试验的优先干预措施。CITP数据协调中心提案提供了一个中央数据库，以支持CITP的工作。总的来说，我们将参与一个独特的团队项目，该项目有能力定义药物干预措施，在不同人群中大力促进健康，并对促进健康人类衰老的疗法的发展产生影响。

Project Summary Health challenges linked to human aging take a tremendous toll on our society. Physical and cognitive decline limit the quality of life for the elderly and their caregivers. Aging is the major risk factor for, and possible cause of cancer, diabetes, and neurodegenerative disease, and thus struggle with debilitating disease is a common health burden for the aging population. Without question, the promotion of healthy aging with extended resistance to decline should be a major objective of current medical research. To investigate healthy aging, simple animals models such as the nematode C. elegans have been studied, providing molecular insights into the genes and chemical compound interventions that can modulate conserved aging processes likely to act similarly in humans. The goal of the proposed work is to continue, and expand, efforts of a co-operative scientific group involving three closely interacting laboratories who coordinately test pharmacological interventions for the ability to extend healthy aging and promote longevity in nematodes. A specific emphasis of this integrated super-group is to test promising drugs on a collection of natural variants of the Caenorhabditis genus, which together represent the extensive genetic heterogeneity in the human population. The idea is that treatments that confer positive outcomes across a diverse population will have an increased chance of being efficacious in higher organisms and will be suggested as priority interventions for testing in pre-clinical mouse studies and possibly future human trials. This CITP Data Coordination Center proposal provides a centralized database to support the work of the CITP. Overall, we will participate in a unique team project that has the power to define pharmacological interventions that robustly promote strong healthspan across a varied population, with implications for development of therapies that promote healthy human aging.