Oklahoma PREVENT: PRogram to Enhance Vaccine Equity in Non-metropolitan and Tribal areas

俄克拉荷马州2010年出生的人的预期寿命在美国排名第五，而美国印第安人的预期寿命最低 最短，比美国平均水平少7.3年。癌症、糖尿病、心血管疾病、关节炎和 自身免疫是导致残疾和早期死亡的主要原因，也是主要健康差距的来源。 在俄克拉荷马州和其他理想州。除了这些疾病，烟草使用、阿片类药物滥用和儿童健康 也是突出的健康问题。俄克拉荷马州共享临床和翻译中心的主要使命 资源(OSCTR)是通过催化这些顶级的临床和转化性研究(CTR)来改善健康 健康优先事项。为了履行其使命，OSCTR整合了卫生专业人员、调查人员和科学工作者 全州范围内29个公共、私人和部落合作伙伴/附属合作伙伴的资源。俄克拉荷马州是一个理想的环境 这些努力归因于慢性病的高发病率，以及大量农村和部落人口的改善 健康结果可以作为跨理念国家的模型。关于部落健康优先事项和健康公平的CTR是 在OSCTR研究机构和部落国家/卫生系统之间建立了牢固的关系。 OSCTR拥有唯一与IDEA-CTR相关联的CAP认证的生物资源库，以及尖端资源 用于数据研究和医疗数据仓库。俄克拉荷马州也有越来越多的初级调查人员 他们正在启动独立的CTR职业生涯(大多数是在OSCTR的帮助下)，机构领导人是 致力于CTR和改善俄克拉荷马人的健康。在这些优势的同时，OSCTR是 利用新的伙伴关系走向预防。尽管许多早期的成功是显而易见的，但CTR 俄克拉荷马州的可持续性及其对公共卫生的影响受到持续的基础设施需求的限制 支持和进一步发展新的临床研究基础设施的需要。因此，要 扩大对农村和部落人口中高流行率疾病的研究，OSCTR正在帮助部落 卫生系统建立CTR基础设施，并通过部落接触股促进互动。至 开展来自多个学科的初级调查人员的独立CTR职业生涯，OSCTR提供培训， 辅导、试点拨款和基础设施。这包括患者登记处、储存库和数据仓库； 招聘和监管支持；生物统计学和流行病学专业知识；以及全面的在线 将调查人员链接到每个OSCTR合作机构和俄克拉荷马州的相关核心设施的资源 创意计划。为了让卫生专业人员、社区和患者参与高度优先的CTR，OSCTR 将开发一个扩展的在线门户网站，以教育患者和提供者关于CTR的知识，并利用 以社区为导向的健康改善组织网络。最后，要有效地开发和分享 在基础设施方面，OSCTR与俄克拉荷马州和其他州的生物医学IDEA项目合作。 总之，这些活动将有助于培养一支关键的调查人员队伍，以维持俄克拉荷马州的CTR 联邦资助、行业赞助的临床试验和地方支持相结合的基础设施。

An Oklahoma born in 2010 has the fifth lowest life-expectancy in the US and American Indians have the shortest, 7.3 years less than the US average. Cancer, diabetes, cardiovascular disease, arthritis, and autoimmunity are leading causes of disability and early mortality, serving as sources of major health disparities in Oklahoma and other IDeA-states. Along with these diseases, tobacco use, opioid abuse, and child health are also prominent health concerns. The primary mission of the Oklahoma Shared Clinical and Translational Resources (OSCTR) is to improve health by catalyzing clinical and translational research (CTR) in these top health priorities. To fulfill its mission, the OSCTR integrates health professionals, investigators, and scientific resources at 29 public, private, and tribal partners/affiliate partners statewide. Oklahoma is an ideal setting for these efforts due to these high rates of chronic diseases, and large rural and tribal populations where improved health outcomes may serve as models across IDeA states. CTR on tribal health priorities and health equity is fostered by strong relationships between OSCTR research institutions and tribal nations/health systems. OSCTR houses the only CAP-certified biorepository affiliated with an IDeA-CTR, and cutting-edge resources for data research and medical data warehouses. Oklahoma also has a growing cadre of junior investigators who are launching independent CTR careers (most with OSCTR assistance), with institutional leaders who are committed to CTR and improving Oklahomans health. Concurrent with these strengths, the OSCTR is leveraging new partnerships to move toward prevention. Although many early successes are evident, CTR sustainability in Oklahoma and its impact on public health are limited by ongoing needs for infrastructure support and by a need for further development of the nascent clinical research infrastructure. Therefore, to expand research into diseases with high prevalence in rural and tribal populations, the OSCTR is helping tribal health systems build CTR infrastructure and fostering interactions through the Tribal Engagement Unit. To launch independent CTR careers of junior investigators from multiple disciplines, the OSCTR provides training, mentoring, pilot grants, and infrastructure. This includes patient registries, repositories, and data warehouses; recruiting and regulatory support; biostatistical and epidemiologic expertise; and comprehensive online resources linking investigators to relevant Core facilities at each OSCTR partner institution and Oklahoma IDeA program. To engage health professionals, communities, and patients in high-priority CTR, the OSCTR will develop an expanded online portal to educate patients and providers on CTR, and leverages a large network of community-oriented health improvement organizations. Finally, to develop and share effective infrastructure, the OSCTR collaborates with biomedical IDeA programs in Oklahoma and other states. Together, these activities will help develop a critical mass of investigators to sustain Oklahoma’s CTR infrastructure with a combination of federal funding, industry-sponsored clinical trials, and local support.