Research Training in Pediatric Infectious Diseases

项目摘要 这份修订后的T32奖励续期申请，自1980年以来一直得到资助，要求支持 在接下来的五年中，每年两名实习生。耶鲁大学儿科传染病学部是 由不同的严肃调查人员组成，他们进行基于实验室或基于临床的 翻译研究和对我们理解发病机制做出重要贡献的人， 流行病学，以及儿童和成人感染的预防。该司还拥有悠久的历史， 挑选和培训积极进取的儿科医生，以便在研究领域从事富有成效的职业，其中许多人 在学术医疗中心、政府机构、非政府组织和行业中担任重要领导角色。 这项提案有什么新内容？我们计划：(1)提供正规的高级教学培训，并与 指导研究，最终将获得健康科学硕士学位或博士学位 调查医学；(2)建立两个正式的研究轨道：基于临床和基于实验室 翻译研究--有机会在任何一条轨道上进行国际研究；(3)增加机会 通过国际组织在中低收入国家开展全球传染病研究 耶鲁大学教师导师/培训师和精选的全球导师在牙买加、巴西和 加纳；(4)通过招募更多的教员导师/培训员，进一步扩大研究员的潜在研究领域 在微生物组、感染接口和免疫系统等重要领域拥有专业知识 和新出现的传染病；(5)扩大T32的申请者池，将博士后学员包括在内 希望沉浸在传染病重大转化研究中的人；(6)增强多样性 通过积极招募在生物医学研究中代表性不足的个人；以及(7)引入新的 该计划的领导力。我们的目标是发现并招募优秀的申请者，帮助他们学习 批判性思考，并获得研究技能和经验，为他们在以下领域的富有成效的职业生涯做准备 对全球重大传染病的临床/转化性研究，将对 改善健康状况。我们描述了一个为每个学员量身定做的计划，但设计的目的是确保 他们都获得了核心能力，能够进行高质量的临床/转化性研究。奠基之石 该培训计划将包括在实验室或临床上进行密切指导和强化的培训 与儿科传染病相关的基础研究。所需的教学培训将通过 由耶鲁大学生物和生物医学科学联合项目提供的研究生水平课程， 公共卫生学院，国家临床医生学者计划(前罗伯特·伍德·约翰逊临床 学者计划)和耶鲁大学研究医学计划。所有受训人员都将拥有个性化的 发展计划和职业指导，以及医生研究员也将接受临床培训，这将导致 获得儿科传染病委员会认证的资格。

Project Summary This revised application for renewal of our T32 award, which has been funded since 1980, requests support for two trainees per year in each of the next five years. The Division of Pediatric Infectious Diseases at Yale is composed of a diverse group of serious investigators who conduct laboratory-based or clinically-based translational research and who have made important contributions to our understanding of the pathogenesis, epidemiology, and prevention of infections in both children and adults. The Division also has a long history of selecting and training highly motivated pediatricians for productive careers in research, many of whom have assumed prominent leadership roles in academic medical centers, government agencies, NGOs, and industry. What is new in this proposal? We plan to: (1) Offer formal advanced didactic training in combination with mentored research that will culminate in either a Master of Health Science degree or a PhD degree in Investigative Medicine; (2) Establish two formal research tracks: clinically-based and laboratory-based translational research – with opportunities for international research in either track; (3) Increase opportunities for conducting global infectious diseases research in low and middle income countries through international collaborative research of Yale faculty mentors/trainers and selected global mentors in Jamaica, Brazil, and Ghana; (4) Further expand potential research areas for fellows by enlisting additional faculty mentors/trainers with expertise in important areas such as the microbiome, the interface of infections and the immune system and emerging infectious diseases; (5) Expand the applicant pool for the T32 to include PhD post-doc trainees who want to be immersed in significant translational research in infectious diseases; (6) Enhance diversity through active recruitment of individuals underrepresented in biomedical research; and (7) Introduce new leadership for the program. Our goals are to identify and to recruit outstanding applicants, to help them learn to think critically, and to acquire research skills and experience that will prepare them for productive careers in clinical/translational research in globally significant infectious diseases that will make a real contribution to improving health. We describe a program that is tailored to each individual trainee, yet is designed to assure that all gain core competencies to be able to perform top quality clinical/translational research. The cornerstone of this training program will consist of a closely mentored and intensive training in laboratory- or clinically- based research related to Pediatric Infectious Diseases. Required didactic training will be available through Graduate level courses offered by the Yale Combined Program in the Biological and Biomedical Sciences, the School of Public Health, the National Clinician Scholars Program (formerly the Robert Wood Johnson Clinical Scholars Program), and the Yale Investigative Medicine Program. All trainees will have individualized development plans and career mentoring, and physician fellows will also receive clinical training that will lead to eligibility for board certification in Pediatric Infectious Diseases.