Enhancements to the SPF Colony to Increase Production and Efficiency in Management

项目摘要/摘要 耶克斯国家灵长类动物研究中心(YNPRC)的艾滋病研究组合继续扩大 非人灵长类的峰值增长约为650万美元(增长30%)就证明了这一点 (NHP)过去八年的艾滋病研究拨款。赠款资金的增长伴随着 非常需要印度血统的无特定病原体(SPF)猕猴作为这方面的动物模型 研究。YNPRC继续在父母赠款(U42)下维持一群SPF猕猴 OD011023)，为艾滋病毒/艾滋病研究提供这些动物。此补充应用程序的标题为“增强功能” 为SPF殖民地增加生产和管理效率“请求支持(1)增加 在SPF菌落中选择U42支持的化合物，最终将 增加繁殖群体的产量和(2)获得一个流动的程序室和新的捕获 提高每年动物检查和殖民地SPF测试效率的隧道。 这项补充提案的目标将有助于加强管理和畜牧业核心。 家长U42奖助金。畜牧业和管理核心的目标是利用资源 由U42提供，以最大限度地生产印度原产恒河猴并促进这些资源的分配 NIH资助的艾滋病毒/艾滋病研究的动物。这一补充应用程序将有助于实现这些目标 以下两个具体目标：(1)建立更多的介绍围栏，以提高 将多只雄性繁殖者引入雌性群体，从而改善成年性别比和动物数量 生产和(2)购买兽医拖车和束缚捕获隧道，以提高工作效率 野战站对SPF群体进行的年度健康调查 实现这些目标将有助于提高产量和加强管理的Yerkes U42支持 SPF繁殖群体，以确保该计划的可持续性，提供必要的动物来支持 艾滋病毒/艾滋病研究计划使用印度血统的恒河猴。这一关键资源的可用性 使用恒河猴模型进行临床前研究的科学家将产生积极而重大的影响 关于开发预防或治愈人类艾滋病毒感染的治疗方法。

Project Summary/ Abstract The AIDS research portfolio at Yerkes National Primate Research Center (YNPRC) has continued to expand as demonstrated by a peak growth of approximately $6.5 million dollars (30% increase) in nonhuman primate (NHP) AIDS research grant funding over the past eight years. This growth in grant funding is accompanied by a high demand for Indian-origin specific pathogen free (SPF) rhesus macaques as the animal model for this research. YNPRC has continued to maintain a colony of SPF rhesus macaques under the parent grant (U42 OD011023) to provide these animals for HIV/AIDS research. This supplement application titled “Enhancements to the SPF Colony to Increase Production and Efficiency in Management” requests support for (1) the addition of novel “introduction enclosures” to select U42 supported compounds in the SPF colony that will ultimately increase production in the breeding colony and (2) the acquisition of a mobile procedure room and new capture tunnels that improve the efficiency of annual animal examinations and SPF testing of the colony. The goals of this supplement proposal will facilitate enhancements to the management and husbandry core in the parent U42 grant. The goals of the husbandry and management core are to leverage the resources provided by the U42 to maximize production of Indian-origin rhesus monkeys and facilitate allocation of these animals for NIH-funded HIV/AIDS research. This supplemental application will contribute to these goals with the following two specific aims: (1) to build additional introduction enclosures to improve the success of the introduction of multiple breeder males to female groups, thereby improving adult sex ratios and animal production and (2) to acquire a veterinary trailer and restraint capture tunnels to improve the efficiency of annual health surveys performed on the SPF colony at the Field Station Achieving these aims will help increase production and enhance management of the Yerkes U42 supported SPF breeding colony to ensure the program is sustainable, providing the necessary animals to support the HIV/AIDS research program using Indian-origin rhesus monkeys. The availability of this critical resource to scientists performing preclinical studies using the rhesus monkey model will have a positive, significant impact on the development of treatments to prevent or cure infection from HIV in people.